The third-generation EGFR tyrosine kinase inhibitor (TKI), osimertinib (Tagrisso) targets EGFR mutations, including T790M. Osimertinib was approved by the FDA in November 2015 for the treatment of patients with metastatic non–small-cell lung cancer NSCLC) and the T790M mutation whose disease progressed during or after EGFR TKI therapy.
More than 33% of patients with heavily pretreated advanced melanoma are still alive at 5 years after starting nivolumab (Opdivo) monotherapy, reported F. Stephen Hodi, Jr, MD, Director of the Melanoma Center, Dana-Farber Cancer Institute, Boston, at the 2016 American Association for Cancer Research (AACR) meeting.
“Intralesional therapy is here to stay,” said Sanjiv S. Agarwala, MD, Section Chief, Hematology/­Oncology, St Luke’s University Health Network, Easton, PA, who moderated a debate on this topic at the recent HemOnc Today Melanoma and Cutaneous Malignancies meeting.
The term telehealth is used interchangeably with telemedicine by some organizations. However, telemedicine is typically associated with the delivery of traditional clinical diagnosis and monitoring by using some form of medical technology, whereas telehealth has a much broader definition that comprises education, disease awareness, and wellness, in addition to the use of technology to connect physicians to patients.
Contemporary treatment has led to improvements in survival for all patients with metastatic testicular germ-cell tumors (GCTs), including poor-risk patients, although they still have worse survival. A new study shows that if poor-risk patients receive curative therapy and survive for at least 2 years, their survival approaches that of favorable-risk and intermediate-risk patients. The study supports no further routine scanning 2 years after diagnosis in surviving patients.
The use of liposomal bupivacaine during major surgery for gynecologic malignancies achieved similar pain control with significantly less use of opioids and patient-controlled analgesia (PCA) as conventional bupivacaine.
More than 50% of women with early-stage endometrial cancer had open surgery, in contradiction to recommendations in clinical guidelines, according to a study reported at the 2016 Society of Gynecologic Oncology (SGO) annual meeting.
The most recent update of the National Comprehensive Cancer Network (NCCN) guideline on breast cancer has undergone a number of “tweaks” with few major changes. The revisions include new recommendations for preoperative endocrine therapy, optimization of adjuvant endocrine therapy in premenopausal and postmenopausal women, an update on HER2-directed therapy for patients with operable breast cancer, and guidance on new agents for endocrine therapy in metastatic disease.
Immunotherapy is a hot topic in cancer right now, with approved checkpoint inhibitors for melanoma and non–small-cell lung cancer. Checkpoint inhibitors are also making inroads in other solid tumors.
An ongoing clinical trial of a novel strategy to evaluate new chemotherapy regimens for patients with early-stage breast cancer has identified another neoadjuvant combination therapy worthy of a phase 3 clinical trial involving patients with HER2-positive breast cancer.
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