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Gout

To reduce gout flares, colchicine or a nonsteroidal anti-inflammatory drug was given 14 days before baseline through month 5, unless patients could not tolerate these prophylactic drugs.
Our findings provide evidence for a potential cardiovascular protective effect of allopurinol in patients with gout and diabetes, a group of patients at high risk for cardiovascular events, the researchers concluded.

A total of 1159 patient charts were abstracted; 230 patients had gout and OA, and 929 had gout without OA. Among patients with gout who were aged ≥61 years, 63.0% were identified as having comorbid OA. The majority of patients in the study were white (71.2%) and men (80.5%). Severity of gout was determined by physician global assessment, number of flares, physician-evaluated damage to organs and/or joints, and tophi.

Gout, a common form of inflammatory arthritis, is caused when uric acid crystals build up in the tissues and fluids of a patient’s body. Symptoms of gout include redness, swelling, pain, heat, and stiffness in joints; the first gout attack often occurs in an individual’s big toe, and can be painful enough to wake them from slumber. Although gout attacks can be treated with medications, such as nonsteroidal anti-inflammatory drugs, certain nonpharmacologic steps may be beneficial in managing or avoiding these flares. The following tips include methods for easing or preventing gout attacks.
Although gout is a common disease that may have serious consequences, numerous studies show that gout is often misdiagnosed and that its management is suboptimal. New evidence-based guidelines for the management of gout from the European League Against Rheumatism (EULAR), published on July 25, 2016, have been developed in the hopes of remedying these issues.
A large proportion of patients with gout have uncontrolled disease, according to recent research published in The Journal of Rheumatology. These patients have significantly worse functioning, quality of life, and work productivity.
Gout is a common and painful condition that is manageable, and treatment guidelines are available. Despite this, several studies suggest management is suboptimal.
New criteria for diagnosing and classifying gout are helping not only researchers but also those working at the bedside.
Although colchicine has been used for centuries to treat gout, research on this drug is still revealing new treatment dimensions, according to a review article by Michael Pillinger, MD, and other clinician-researchers.
Although the efficacy of febuxostat has been shown in el­derly patients, its efficacy is unclear in elderly women with hyperuricemia.
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